[CAS NO. 335165-68-9] BAI1
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PRODUCTS SPECIFICATIONS [335165-68-9]
Catelog
SLK-S8865
Brand
Selleck
CAS
335165-68-9
DESCRIPTION [335165-68-9]
Overview
| MDL | MFCD00687415 |
|---|---|
| Molecular Weight | 467.20 |
| Molecular Formula | C19H21Br2N3O |
| SMILES | OC(CN1CCNCC1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1404 mL | 10.7021 mL | 21.4041 mL |
| 5 mM | 0.4281 mL | 2.1404 mL | 4.2808 mL |
| 10 mM | 0.2140 mL | 1.0702 mL | 2.1404 mL |
| 50 mM | - | - | - |
Description
BAI1 is a direct allosteric inhibitor of with a dissociation constant (Kd) of 15.0 ± 4 μM.
Targets
| Bax [1] (Cell-free assay) |
| 15.0 μM(Kd) |
In vitro
BAX activation inhibitor 1 (BAI1) demonstrates inhibition of tBID-induced BAX-mediated membrane permeabilization in a dose dependent manner with an IC50 of 3.3 μM. BAI1 binds to monomeric BAX at a novel allosteric site. BAI1 is a potent inhibitor of BAX conformational activation and oligomerization in solution, not by direct competition with the activator, but rather through an allosteric mechanism that favors the inactive BAX. Moreover, BAI1 inhibited BAX membrane association and translocation induced either by tBID (IC50 = 5 ± 1 μΜ) or BIM SAHB (IC50 = 2 ± 1 μΜ) in a dose dependent manner and with a similar IC50 to BAX-mediated liposomal release. BAI1 selectively inhibits BAX-dependent cell death.
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