[CAS NO. 1660114-31-7] NIK SMI1
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PRODUCTS SPECIFICATIONS [1660114-31-7]
Catalog
SLK-S8941
Brand
Selleck
CAS
1660114-31-7
DESCRIPTION [1660114-31-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 365.38 |
| Molecular Formula | C20H19N3O4 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7369 mL | 13.6844 mL | 27.3688 mL |
| 5 mM | 0.5474 mL | 2.7369 mL | 5.4738 mL |
| 10 mM | 0.2737 mL | 1.3684 mL | 2.7369 mL |
| 50 mM | 0.0547 mL | 0.2737 mL | 0.5474 mL |
Description
NIK SMI1 is a highly potent and selective inhibitor with Ki of 0.23 nM for NIK-catalyzed hydrolysis of ATP to ADP.
Targets
| NIK-catalyzed hydrolysis of ATP to ADP [1] |
| 0.23 nM(Ki) |
In vitro
NIK SMI1 exhibits selective inhibition of LTβR-dependent p52 translocation and transcription of NF-κB2 related genes. NIK SMI1 is shown to have a favorable pharmacokinetic profile across species and to inhibit BAFF-induced B cell survival in vitro.
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