[CAS NO. 1281870-42-5] Rhosin hydrochloride
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PRODUCTS SPECIFICATIONS [1281870-42-5]
Catalog
SLK-S8988
Brand
Selleck
CAS
1281870-42-5
DESCRIPTION [1281870-42-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 394.86 |
| Molecular Formula | C20H19ClN6O |
| SMILES | O=C(N/N=C/C1=CC=C2N=CC=NC2=C1)[C@H](N)CC3=CNC4=C3C=CC=C4.[H]Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5325 mL | 12.6627 mL | 25.3254 mL |
| 5 mM | 0.5065 mL | 2.5325 mL | 5.0651 mL |
| 10 mM | 0.2533 mL | 1.2663 mL | 2.5325 mL |
| 50 mM | 0.0507 mL | 0.2533 mL | 0.5065 mL |
Description
Rhosin (G04) hydrochloride (HCl) is a potent, specific inhibitor of RhoA subfamily GTPases with Kd of ~ 0.4 uM. Rhosin hydrochloride induces cell .
Targets
| Rho [1] (Cell-free assay) |
| 0.4 μM(Kd) |
In vitro
In cells Rhosin specifically inhibits RhoA activity and RhoA-mediated cellular function without affecting Cdc42 or Rac1 signaling activities. By suppressing RhoA or RhoC activity Rhosin can inhibit mammary sphere formation by breast cancer cells, suppress invasion of mammary epithelial cells, and induce neurite outgrowth of PC12 cells in synergy with NGF.
References
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