[CAS NO. 81267-65-4] Phenoxodiol (Haginin E)

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PRODUCTS SPECIFICATIONS [81267-65-4]

Catalog

SLK-S9634

Brand

Selleck

CAS

81267-65-4

DESCRIPTION [81267-65-4]

Overview

MDL	-
Molecular Weight	240.25
Molecular Formula	C15H12O3
SMILES	OC=1C=C2C(C=C(CO2)C3=CC=C(O)C=C3)=CC1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.1623 mL	20.8117 mL	41.6233 mL
5 mM	0.8325 mL	4.1623 mL	8.3247 mL
10 mM	0.4162 mL	2.0812 mL	4.1623 mL
50 mM	0.0832 mL	0.4162 mL	0.8325 mL

Description

Phenoxodiol (Haginin E, Idronoxil, Dehydroequol, NV 06, PXD) is an isoflavone analog with antineoplastic activity that activates the system, inhibits , and disrupts expression, resulting in tumor cell . Phenoxodiol also inhibits .

Targets

Caspase ^[1]

XIAP ^[1]

FLIP ^[1]

Topo II ^[2]

In vitro

Primary ovarian cancer cells, isolated from ascitic fluids of ovarian cancer patients, resistant to conventional chemotherapy, undergo apoptosis following phenoxodiol treatment. This effect is dependent upon the activation of the caspase system, inhibiting XIAP, an inhibitor of apoptosis, and disrupting FLICE inhibitory protein (FLIP) expression through the Akt signal transduction pathway. Phenoxodiol is an efficient inducer of cell death in ovarian cancer cells and sensitizes the cancer cells to Fas-mediated apoptosis.

References

[1] Marijke Kamsteeg, et al. Oncogene. 2003 May 1;22(17):2611-20.
[2] Andreas I Constantinou, Alan Husband. Anticancer Res. Sep-Oct 2002;22(5):2581-5.
[3]Toni K Choueiri, et al. Curr Oncol Rep. 2006 Mar;8(2):104-7.
[4] Sylvianna Georgaki, et al. J Cell Mol Med. 2009 Sep;13(9B):3929-38.

Synonyms

2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-

3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol

Haginin E

Phenoxodiol

Dehydroequol

NV 06

Idronoxil

3-(4-Hydroxyphenyl)-2H-benzopyran-7-ol

D 7446