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Catalog:
SLK-S9634
Brand:
Selleck
CAS:
81267-65-4
Overview
MDL
-
Molecular Weight
240.25
Molecular Formula
C15H12O3
SMILES
OC=1C=C2C(C=C(CO2)C3=CC=C(O)C=C3)=CC1
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
4.1623 mL
20.8117 mL
41.6233 mL
5 mM
0.8325 mL
4.1623 mL
8.3247 mL
10 mM
0.4162 mL
2.0812 mL
4.1623 mL
50 mM
0.0832 mL
0.4162 mL
0.8325 mL
Description
Phenoxodiol (Haginin E, Idronoxil, Dehydroequol, NV 06, PXD) is an isoflavone analog with antineoplastic activity that activates the system, inhibits , and disrupts expression, resulting in tumor cell . Phenoxodiol also inhibits .
Primary ovarian cancer cells, isolated from ascitic fluids of ovarian cancer patients, resistant to conventional chemotherapy, undergo apoptosis following phenoxodiol treatment. This effect is dependent upon the activation of the caspase system, inhibiting XIAP, an inhibitor of apoptosis, and disrupting FLICE inhibitory protein (FLIP) expression through the Akt signal transduction pathway. Phenoxodiol is an efficient inducer of cell death in ovarian cancer cells and sensitizes the cancer cells to Fas-mediated apoptosis.
