[CAS NO. 150651-39-1] iFSP1
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PRODUCTS SPECIFICATIONS [150651-39-1]
Catelog
SLK-S9663
Brand
Selleck
CAS
150651-39-1
DESCRIPTION [150651-39-1]
Overview
| MDL | MFCD01572665 |
|---|---|
| Molecular Weight | 323.35 |
| Molecular Formula | C20H13N5 |
| SMILES | N#CC1=C(N)N2C(C(C#N)=C1C3=CC=C(C)C=C3)=NC4=CC=CC=C42 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0926 mL | 15.4631 mL | 30.9262 mL |
| 5 mM | 0.6185 mL | 3.0926 mL | 6.1852 mL |
| 10 mM | 0.3093 mL | 1.5463 mL | 3.0926 mL |
| 50 mM | 0.0619 mL | 0.3093 mL | 0.6185 mL |
Description
iFSP1 is a potent, selective and glutathione-independent inhibitor of with EC50 of 103 nM. iFSP1 selectively induces in GPX4-knockout Pfa1 and HT1080 cells that overexpresses FSP1.
Targets
| FSP1/AIFM2 [1] (Cell-free assay) |
| 103 nM(EC50) |
In vitro
iFSP1 selectively induces ferroptosis in GPX4-knockout Pfa1 and HT1080 cells that overexpressed FSP1. FSP1 is expressed in most tumour cell lines, and iFSP1 treatment robustly sensitizes these cells to RSL3-induced ferroptosis.
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