[CAS NO. 313380-27-7] FDI-6

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PRODUCTS SPECIFICATIONS [313380-27-7]

Catalog

SLK-S9689

Brand

Selleck

CAS

313380-27-7

DESCRIPTION [313380-27-7]

Overview

MDL	MFCD01416826
Molecular Weight	437.43
Molecular Formula	C19H11F4N3OS2
SMILES	O=C(C1=C(N)C2=C(C(F)(F)F)C=C(C3=CC=CS3)N=C2S1)NC4=CC=C(F)C=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.2861 mL	11.4304 mL	22.8608 mL
5 mM	0.4572 mL	2.2861 mL	4.5722 mL
10 mM	0.2286 mL	1.1430 mL	2.2861 mL
50 mM	0.0457 mL	0.2286 mL	0.4572 mL

Description

FDI-6 (NCGC00099374) is an inhibitor of the with IC50 of 22.5 μM.

Targets

FOXM1 ^[1]
(Cell-free assay)

22.5 μM

In vitro

FDI-6 (NCGC00099374) is characterized in depth and is shown to bind directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induces concomitant transcriptional down-regulation. Global transcript profiling of MCF-7 cells by RNA-seq shows that FDI-6 specifically down-regulates FOXM1-activated genes with FOXM1 occupancy confirmed by ChIP-seq.

References

[1] Michael V Gormally, et al. Nat Commun. 2014 Nov 12;5:5165.
[2] Yuan Li, et al. Hepatology. 2020 Feb 21;10.1002/hep.31196.