[CAS NO. 1197824-15-9] EN4
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PRODUCTS SPECIFICATIONS [1197824-15-9]
Catelog
SLK-S9807
Brand
Selleck
CAS
1197824-15-9
DESCRIPTION [1197824-15-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 416.47 |
| Molecular Formula | C25H24N2O4 |
| SMILES | O=C(NC1=CC=CC=C1OC2=CC=C(OCC)C=C2)C3=CC=C(CNC(C=C)=O)C=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4011 mL | 12.0057 mL | 24.0113 mL |
| 5 mM | 0.4802 mL | 2.4011 mL | 4.8023 mL |
| 10 mM | 0.2401 mL | 1.2006 mL | 2.4011 mL |
| 50 mM | 0.0480 mL | 0.2401 mL | 0.4802 mL |
Description
EN4, a covalent ligand that targets cysteine 171 (C171) of , is selective for over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis.
Targets
| MYC [1] |
In vitro
EN4 directly targets MYC in cells, reduces MYC and MAX thermal stability, inhibits MYC transcriptional activity, downregulates multiple MYC transcriptional targets, and impairs tumorigenesis. EN4 treatment significantly impairs 231MFP breast cancer cell proliferation in a dose- and time-dependent manner. EN4 impairs the cell survival of MYC transformed mammary epithelial MCF10A cells, but not parental MCF10A cells that are not dependent on MYC.
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