[CAS NO. 1197824-15-9]  EN4

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PRODUCTS SPECIFICATIONS [1197824-15-9]

Catelog
SLK-S9807
Brand
Selleck
CAS
1197824-15-9

DESCRIPTION [1197824-15-9]

Overview

MDL-
Molecular Weight416.47
Molecular FormulaC25H24N2O4
SMILESO=C(NC1=CC=CC=C1OC2=CC=C(OCC)C=C2)C3=CC=C(CNC(C=C)=O)C=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.4011 mL12.0057 mL24.0113 mL
5 mM0.4802 mL2.4011 mL4.8023 mL
10 mM0.2401 mL1.2006 mL2.4011 mL
50 mM0.0480 mL0.2401 mL0.4802 mL

Description

EN4, a covalent ligand that targets cysteine 171 (C171) of , is selective for over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis.

Targets

MYC [1]

In vitro

EN4 directly targets MYC in cells, reduces MYC and MAX thermal stability, inhibits MYC transcriptional activity, downregulates multiple MYC transcriptional targets, and impairs tumorigenesis. EN4 treatment significantly impairs 231MFP breast cancer cell proliferation in a dose- and time-dependent manner. EN4 impairs the cell survival of MYC transformed mammary epithelial MCF10A cells, but not parental MCF10A cells that are not dependent on MYC.